13th Street is another of Brauner's paintings that needs to be destroyed in order to enter his Lost Gallery. At the beginning, both Jonathan and Charlotte must use the power granted by the Strength Glove to stop a locomotive and continue into the city.
- Completing 13th Street makes Wind's "The Nest of Evil" quest available.
- In Richter, Sisters and Old Axe Armor Modes, an additional Bone Ark and an additional Vapula will appear on the train tracks where the train was in Normal Mode.
- Nest of Evil - Completing 13th Street makes Wind's "The Nest of Evil" quest available at the Entrance. The player may opt to fulfill this quest's requirement (have an 888% map rate explored) first, before venturing through the rest of the game.